The first two consecutive numbers to have two distinct prime factors are: ~~~ 14 = 2 × 7 15 = 3 × 5 ~~~ The first three consecutive numbers to have three distinct prime factors are: ~~~ 644 = 2 × 2 × 7 × 23 645 = 3 × 5 × 43 646 = 2 × 17 × 19. ~~~ Find the first four consecutive integers to have four distinct prime factors. What is the first of these numbers?